Roma Asrani was born to a family from Delhi, who later settled in Chennai. Her father Muralidhar and mother Madhu run a wholesale jewellery shop in Chennai.
She made her entry into Malayalam films with the movie Notebook, directed by Roshan Andrews and became very popular after the success of the film. For her performance in Notebook she was adjudged best newcomer by Kerala Film Critics Association, Asianet, Amrita TV and Kalakeralam. Her second film July 4 (2007),directed by Joshiy however, was a flop.But it was a notable one. Her movie Chocolate (2007) with Prithviraj was a big hit, and this movie was a turning point in her career. She has also acted in a music album by the band Team Malayalee with popular singer Vineeth Sreenivasan and actor Prithviraj for the number Minnel Azhake which was a big hit in south India.
Roma has also acted in the Telugu movie Mr. Errababu (2005) and the Tamil movie Kathale En Kathale (2006). She made her Kannada début with Aramane (2007), starring Ganesh in the lead. Further, she reappeared in the Telugu industry after a break in the movie Chalaki in 2010.She has acted in some advertisements.